Process Chemistry


Process Chemistry

Process development work for the Active Pharmaceutical Ingredients (APIs) is carried out by the Chemical Process Research Laboratory, which focuses on developing commercially viable eco-friendly processes for intermediates and APIs for the regulated global markets.

Capabilities

Chemistry

  • Heterocyclic chemistry
  • Catalytic hydrogenations
  • Organic transformations of wide and varied types
  • Classical and dynamic resolutions
  • Asymmetric synthesis using chiral pool, enantio /diastereo-selective reactions
  • Polymer Chemistry
  • Green chemistry
  • Biocatalysis

Process

  • Development of novel/non-infringing processes for APIs
  • Development of environment friendly processes
  • Development of Chiral APIs
  • Ability to comply with ICH guidelines
  • Synthesis, isolation and characterization of impurities
  • Expertise in handling pyrophoric reagents
  • Expertise in very low temperature (-85 deg C) reactions

Analytical

  • Development of in-process analytical methods
  • Isolation and identification of impurities
  • Enantiomer separation using chiral HPLC/GC columns
  • Preparative TLC/HPLC

Polymorphism

  • Synthesis of novel Polymorphs
  • Synthesis of amorphous forms using lyophilization, spray drying or solvent evaporation techniques
  • Development of novel processes for known Polymorphs
  • Quantification studies of Polymorphs using IR/DSC/XRPD
  • Determination of Polymorph stability
Infrastructure
  • Modern laboratory supported by state-of-the-art instrumentation facility
  • On-line search facilities for information mining
  • 1 to 25 L capacity high pressure SS/Glass/Hastalloy autoclaves
  • Parallel synthesizer with calorimetric probe
  • GCs, HPLCs
  • Micronisation facilities to obtain particle size right from <5
  • Surface area determination
  • X-ray crystallographic capabilities for polymorphism studies
  • Multipurpose plant with a combination of 21 GLR and SS reactors
  • Preparative scale HPLC
  • 2L Autolab system with calorimetry





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