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CHEMICAL PROCESS

 

Process development work for APIs is carried out by the Chemical Process Research Laboratory, which focuses on developing commercially viable eco-friendly processes for intermediates and APIs for the regulated global markets.

Capabilities

Chemistry

  • Heterocyclic Chemistry
  • Catalytic Hydrogenations
  • Capability for wide and varied types of organic transformations
  • Classical and Dynamic Resolutions
  • Asymmetric synthesis using Chiral Pool, enantio /diastereo-selective reactions
  • Polymer Chemistry
  • Green Chemistry

Process

  • Develop novel/non-infringing process for APIs
  • Develop environment friendly processes
  • Development of Chiral APIs
  • Ability to comply with ICH guidelines
  • Synthesis, isolation and characterizations of impurities
  • Expertise in handling pyrophoric re-agents
  • Expertise in very low temperature (-85 deg C) reactions

Analytical

  • Develop in-process analytical methods
  • Isolation and Identification of impurities
  • Enantiomer separation using Chiral HPLC/GC columns
  • Preparative TLC/HPLC

Polymorphism:

  • Synthesis of Novel Polymorphs
  • Development of novel processes for known Polymorphs
  • Quantification studies of Polymorphs using IR/DSC/XRPD
  • Determination of Polymorph stability
Achievements

Processes for 39 APIs developed

  • 21 API processes validated
  • 11 under scale-up
  • 7 under development
Infrastructure
  • Modern laboratory supported by state-of-the-art instrumentation facility
  • On-line search facilities for information mining
  • 1 to 25 L capacity high pressure SS/Glass/Hastalloy autoclaves
  • Parallel synthesizer with calorimetric probe
  • GCs, HPLCs
  • Micronisation facilities to obtain particle size right from <5
  • Surface area determination
  • X-ray crystallographic capabilities for polymorphism studies
  • Scale-up laboratory with cGMP compliant finish area
  • Multipurpose plant with a combination of 21 GLR and SS reactors

Disclaimers: Products under patents are offered for sale only in those countries where patents have expired.

 
 
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