| Process development
work for APIs is carried out by the Chemical Process Research Laboratory,
which focuses on developing commercially viable eco-friendly processes
for intermediates and APIs for the regulated global markets.
| Capabilities |
Chemistry |
- Heterocyclic Chemistry
- Catalytic Hydrogenations
- Capability for wide and varied types of
organic transformations
- Classical and Dynamic Resolutions
- Asymmetric synthesis using Chiral Pool,
enantio /diastereo-selective reactions
- Polymer Chemistry
- Green Chemistry
|
Process |
- Develop novel/non-infringing process for
APIs
- Develop environment friendly processes
- Development of Chiral APIs
- Ability to comply with ICH guidelines
- Synthesis, isolation and characterizations
of impurities
- Expertise in handling pyrophoric re-agents
- Expertise in very low temperature (-85
deg C) reactions
|
Analytical |
- Develop in-process analytical methods
- Isolation and Identification of impurities
- Enantiomer separation using Chiral HPLC/GC
columns
- Preparative TLC/HPLC
|
Polymorphism: |
- Synthesis of Novel Polymorphs
- Development of novel processes for known
Polymorphs
- Quantification studies of Polymorphs using
IR/DSC/XRPD
- Determination of Polymorph stability
|
| Achievements |
| Processes for 39 APIs developed
|
- 21 API processes validated
- 11 under scale-up
- 7 under development
|
| Infrastructure |
- Modern laboratory supported by state-of-the-art
instrumentation facility
- On-line search facilities for information
mining
- 1 to 25 L capacity high pressure SS/Glass/Hastalloy
autoclaves
- Parallel synthesizer with calorimetric
probe
- GCs, HPLCs
- Micronisation facilities to obtain particle
size right from <5
- Surface area determination
- X-ray crystallographic capabilities for
polymorphism studies
- Scale-up laboratory with cGMP compliant
finish area
- Multipurpose plant with a combination
of 21 GLR and SS reactors
|
Disclaimers: Products under patents are offered
for sale only in those countries where patents have expired. | 
